Nanomedicine for periodontal disease

13 Feb Nanomedicine for periodontal disease

February 3, 2015 (Radboud University)

Periodontal diseases, including periodontitis and peri-implantitis, are oral infections associated with inflammation-mediated loss of the periodontal ligament (PDL) and/or supporting alveolar bone, which finally results in tooth/implant loss. Clinical treatment of periodontal diseases is very costly and time consuming.

Prof.dr. John Jansen and Dr. Fang Yang, Department Biomaterials, Radboud University Medical Center team up with Prof.dr. Alan Rowan, Cluster Molecular Chemistry, Radboud University to develop a more efficient therapy. They explore the efficacy of an injectable biomolecule delivery system, which includes a nanofibrous polyisocyanide gel, polyglycolic-lactid acid microspheres and pro-resolving agents to resolve inflammation.

The polyisocyanide gel – discovered by Rowan – stiffens in a warm environment .

The knowledge obtained from this project named BioPerio can also be used for treatment of other inflammatory diseases, including peritonitis, dermal inflammation and rheumatoid arthritis.

Technology Foundation STW granted the BioPerio-project 350.000 euro recently. BioPerio is part of the Radboud Nanomedicine Alliance.


In another project, the use of the supergel for wound dressing will be the topic of research.

Source: Radboud University

Secmatix and NovioTech are partners in this project with their own contributions

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